All matchups
Los Angeles Rams @ Buffalo Bills
Sunday, September 27 at 1:00 PM EDT
LA
+3
+136
Total
48.5
BUF
-3
-162
The Read
Buffalo Bills open a 3-point favorite over Los Angeles Rams — about 62% implied to win outright. The 48.5 total prices it near 26–23, one of the week's higher totals.
Los Angeles Rams went 12–5 in 2025 — #3 of 32 by point differential (+10.1/g).
Buffalo Bills went 12–5 in 2025 — #6 of 32 by point differential (+6.8/g).
2025 team profiles
Los Angeles Rams
2025 record12-5Point diff / game+10.1Pythag wins (rank)12.3 (#3)2026 SOS rank#13
Buffalo Bills
2025 record12-5Point diff / game+6.8Pythag wins (rank)11.2 (#6)2026 SOS rank#8