All matchups
Arizona Cardinals @ Los Angeles Rams
Sunday, September 13 at 4:25 PM EDT
ARI
+11.5
+455
Total
46.5
LA
-11.5
-625
The Read
Los Angeles Rams open a 11.5-point favorite over Arizona Cardinals — about 86% implied to win outright. The 46.5 total prices it near 29–18.
Arizona Cardinals went 3–14 in 2025 — #29 of 32 by point differential (-7.8/g), and were 2.4 wins unlucky versus their margin.
Los Angeles Rams went 12–5 in 2025 — #3 of 32 by point differential (+10.1/g).
Arizona Cardinals face one of the NFL's toughest 2026 schedules (strength of schedule #3).
2025 team profiles
Arizona Cardinals
2025 record3-14Point diff / game-7.8Pythag wins (rank)5.4 (#29)2026 SOS rank#3
Los Angeles Rams
2025 record12-5Point diff / game+10.1Pythag wins (rank)12.3 (#3)2026 SOS rank#13