San Francisco 49ers open a 11.5-point favorite over Arizona Cardinals — about 85% implied to win outright. The 46.5 total prices it near 29–18.

Arizona Cardinals went 3–14 in 2025 — #29 of 32 by point differential (-7.8/g), and were 2.4 wins unlucky versus their margin.

San Francisco 49ers went 12–5 in 2025 — #8 of 32 by point differential (+3.9/g), but +1.9 of those wins outran their scoring margin, a regression flag.

Arizona Cardinals face one of the NFL's toughest 2026 schedules (strength of schedule #3).