Sunday, September 27 at 4:05 PM EDT
ARI
+8.5
+360
Total
47.5
SF
-8.5
-470
Bet it or track it
Tap a price to send it to your DraftKings betslip. Tail it and it grades into My Record once the game is final — pushes settle as pushes, which matters when 3 decides one NFL game in seven.
How games at these numbers have gone
- Spread 8.5 — the 7-10 point band. In 1,270 games since 1999 the favorite covered 48.4% of the time — a coin flip once the 95% range (45.6–51.1%) is taken into account.
- Total 47.5 — spread in the 7-10 point band. Games with a spread this size went over 50.4% of the time across 1,281 of them.
Last three seasons
ARI
18-17 ATS · 12-23 SU · 18-16 O/U
SF
18-19 ATS · 20-17 SU · 21-15 O/U
15-10 ATS as a favorite
Measured on 7,276 games with a closing line and a final score. Records cover three seasons and describe the team — they are not a signal, and every situational split we measured lands at a coin flip. Context, not a pick — see every band.
The Read
San Francisco 49ers open a 8.5-point favorite over Arizona Cardinals — about 82% implied to win outright. The 47.5 total prices it near 28–20.
Arizona Cardinals went 3–14 in 2025 — #29 of 32 by point differential (-7.8/g), and were 2.4 wins unlucky versus their margin.
San Francisco 49ers went 12–5 in 2025 — #8 of 32 by point differential (+3.9/g), but +1.9 of those wins outran their scoring margin, a regression flag.
Arizona Cardinals face one of the NFL's toughest 2026 schedules (strength of schedule #3).
2025 team profiles
Arizona Cardinals
San Francisco 49ers