San Francisco 49ers open a 2.5-point favorite over Denver Broncos — about 59% implied to win outright. The 46.5 total prices it near 25–22.

Denver Broncos went 14–3 in 2025 — #7 of 32 by point differential (+5.3/g), but +3.0 of those wins outran their scoring margin, a regression flag.

San Francisco 49ers went 12–5 in 2025 — #8 of 32 by point differential (+3.9/g), but +1.9 of those wins outran their scoring margin, a regression flag.