Bobby's Bets
Bobby's BetsNFL Analytics
All matchups
DET
Detroit Lions @ Buffalo Bills
BUF

Thursday, September 17 at 8:15 PM EDT

DET

+4.5

+185

Total

54.5

BUF

-4.5

-225

Bet it or track it

Tap a price to send it to your DraftKings betslip. Tail it and it grades into My Record once the game is final — pushes settle as pushes, which matters when 3 decides one NFL game in seven.

SpreadDET +4.5-108
SpreadBUF -4.5-112
TotalOver 54.5-108
TotalUnder 54.5-112
MoneylineDET to win+185
MoneylineBUF to win-225

How games at these numbers have gone

  • The key number. 4.5 sits half a point past 4, one of the margins games actually land on. That hook is most of what you are paying for or getting here.
  • Spread 4.5 — the 4-6 point band. In 1,055 games since 1999 the favorite covered 49.2% of the time — a coin flip once the 95% range (46.2–52.2%) is taken into account.
  • Total 54.5 — spread in the 3-7 point band. Games with a spread this size went over 49.5% of the time across 3,551 of them.

Last three seasons

DET

20-15-1 ATS · 25-11 SU · 21-14 O/U

17-11-1 ATS as a favorite

BUF

22-18 ATS · 29-11 SU · 24-15 O/U

went over in 24 of 39

Measured on 7,276 games with a closing line and a final score. Records cover three seasons and describe the team — they are not a signal, and every situational split we measured lands at a coin flip. Context, not a pick — see every band.

The Read

Buffalo Bills open a 4.5-point favorite over Detroit Lions — about 69% implied to win outright. The 54.5 total prices it near 30–25, one of the week's higher totals.

Detroit Lions went 9–8 in 2025 — #10 of 32 by point differential (+4.0/g).

Buffalo Bills went 12–5 in 2025 — #6 of 32 by point differential (+6.8/g).

Detroit Lions drew one of the softest 2026 slates (strength of schedule #27).

2025 team profiles

Detroit Lions

2025 record9-8Point diff / game+4.0Pythag wins (rank)10.0 (#10)2026 SOS rank#27

Buffalo Bills

2025 record12-5Point diff / game+6.8Pythag wins (rank)11.2 (#6)2026 SOS rank#8

Props on the board — DET @ BUF