Buffalo Bills open a 3-point favorite over Detroit Lions — about 61% implied to win outright. The 52.5 total prices it near 28–25, one of the week's higher totals.

Detroit Lions went 9–8 in 2025 — #10 of 32 by point differential (+4.0/g).

Buffalo Bills went 12–5 in 2025 — #6 of 32 by point differential (+6.8/g).

Detroit Lions drew one of the softest 2026 slates (strength of schedule #27).