

Thursday, September 17 at 8:15 PM EDT
DET
+4.5
+185
Total
54.5
BUF
-4.5
-225
Bet it or track it
Tap a price to send it to your DraftKings betslip. Tail it and it grades into My Record once the game is final — pushes settle as pushes, which matters when 3 decides one NFL game in seven.
How games at these numbers have gone
- The key number. 4.5 sits half a point past 4, one of the margins games actually land on. That hook is most of what you are paying for or getting here.
- Spread 4.5 — the 4-6 point band. In 1,055 games since 1999 the favorite covered 49.2% of the time — a coin flip once the 95% range (46.2–52.2%) is taken into account.
- Total 54.5 — spread in the 3-7 point band. Games with a spread this size went over 49.5% of the time across 3,551 of them.
Last three seasons
DET
20-15-1 ATS · 25-11 SU · 21-14 O/U
17-11-1 ATS as a favorite
BUF
22-18 ATS · 29-11 SU · 24-15 O/U
went over in 24 of 39
Measured on 7,276 games with a closing line and a final score. Records cover three seasons and describe the team — they are not a signal, and every situational split we measured lands at a coin flip. Context, not a pick — see every band.
The Read
Buffalo Bills open a 4.5-point favorite over Detroit Lions — about 69% implied to win outright. The 54.5 total prices it near 30–25, one of the week's higher totals.
Detroit Lions went 9–8 in 2025 — #10 of 32 by point differential (+4.0/g).
Buffalo Bills went 12–5 in 2025 — #6 of 32 by point differential (+6.8/g).
Detroit Lions drew one of the softest 2026 slates (strength of schedule #27).
2025 team profiles
Detroit Lions
Buffalo Bills
