Bobby's Bets
Bobby's BetsNFL Analytics
All matchups
LAC
Los Angeles Chargers @ Buffalo Bills
BUF

Sunday, September 27 at 1:00 PM EDT

LAC

+4.5

+180

Total

49.5

BUF

-4.5

-218

Bet it or track it

Tap a price to send it to your DraftKings betslip. Tail it and it grades into My Record once the game is final — pushes settle as pushes, which matters when 3 decides one NFL game in seven.

SpreadLAC +4.5-110
SpreadBUF -4.5-110
TotalOver 49.5-110
TotalUnder 49.5-110
MoneylineLAC to win+180
MoneylineBUF to win-218

How games at these numbers have gone

  • The key number. 4.5 sits half a point past 4, one of the margins games actually land on. That hook is most of what you are paying for or getting here.
  • Spread 4.5 — the 4-6 point band. In 1,055 games since 1999 the favorite covered 49.2% of the time — a coin flip once the 95% range (46.2–52.2%) is taken into account.
  • Total 49.5 — spread in the 3-7 point band. Games with a spread this size went over 49.5% of the time across 3,551 of them.

Last three seasons

LAC

22-15 ATS · 22-15 SU · 16-21 O/U

22-15 against the spread

BUF

22-18 ATS · 29-11 SU · 24-15 O/U

went over in 24 of 39

Measured on 7,276 games with a closing line and a final score. Records cover three seasons and describe the team — they are not a signal, and every situational split we measured lands at a coin flip. Context, not a pick — see every band.

The Read

Buffalo Bills open a 4.5-point favorite over Los Angeles Chargers — about 69% implied to win outright. The 49.5 total prices it near 27–23, one of the week's higher totals.

Los Angeles Chargers went 11–6 in 2025 — #13 of 32 by point differential (+1.6/g), but +1.7 of those wins outran their scoring margin, a regression flag.

Buffalo Bills went 12–5 in 2025 — #6 of 32 by point differential (+6.8/g).

2025 team profiles

Los Angeles Chargers

2025 record11-6Point diff / game+1.6Pythag wins (rank)9.3 (#13)2026 SOS rank#9

Buffalo Bills

2025 record12-5Point diff / game+6.8Pythag wins (rank)11.2 (#6)2026 SOS rank#8

Props on the board — LAC @ BUF