San Francisco 49ers open a 10.5-point favorite over Miami Dolphins — about 85% implied to win outright. The 46.5 total prices it near 29–18.

Miami Dolphins went 7–10 in 2025 — #24 of 32 by point differential (-4.5/g).

San Francisco 49ers went 12–5 in 2025 — #8 of 32 by point differential (+3.9/g), but +1.9 of those wins outran their scoring margin, a regression flag.

Miami Dolphins face one of the NFL's toughest 2026 schedules (strength of schedule #2).