All matchups
Seattle Seahawks @ Arizona Cardinals
Sunday, September 20 at 4:25 PM EDT
SEA
-10
-500
Total
44.5
ARI
+10
+380
The Read
Seattle Seahawks open a 10-point favorite over Arizona Cardinals — about 83% implied to win outright. The 44.5 total prices it near 27–17.
Seattle Seahawks went 14–3 in 2025 — #1 of 32 by point differential (+11.2/g).
Arizona Cardinals went 3–14 in 2025 — #29 of 32 by point differential (-7.8/g), and were 2.4 wins unlucky versus their margin.
Arizona Cardinals face one of the NFL's toughest 2026 schedules (strength of schedule #3).
2025 team profiles
Seattle Seahawks
2025 record14-3Point diff / game+11.2Pythag wins (rank)13.0 (#1)2026 SOS rank#14
Arizona Cardinals
2025 record3-14Point diff / game-7.8Pythag wins (rank)5.4 (#29)2026 SOS rank#3