Seattle Seahawks open a 3.5-point favorite over San Francisco 49ers — about 66% implied to win outright. The 48.5 total prices it near 26–23, one of the week's higher totals.

San Francisco 49ers went 12–5 in 2025 — #8 of 32 by point differential (+3.9/g), but +1.9 of those wins outran their scoring margin, a regression flag.

Seattle Seahawks went 14–3 in 2025 — #1 of 32 by point differential (+11.2/g).